The follicles are cytologically polymorphous, are often polarized, and vary in size and shape. The surface of the tongue in this area is made up primarily of lymphoid tissue known as the lingual tonsil. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Lymphoid Hyperplasia Pulmonary lymphoid hyperplasia, also known as follicular bronchiolitis, is an uncommon, benign condition characterized histologically by the presence of polyclonal lymphoid aggregates along the bifurcation of the bronchioles and along the pulmonary lymphatics. Cyclophosphamide, doxorubicin, vincristine, prednisone, Peripheral T cell lymphoma, not otherwise specified. 2000;46:2112. Accessibility All DLBCL cases were positive for CD20, Mum1,Bcl-2 and Bcl-6 and negative for CD5. The therapeutic response is related to the pathological subtype and several factors, such as old age, high grade histology, bulky lymph nodes, higher IPI score, and advanced stage [22, 24, 25]. 1998;112:9914. Squamous hyperplasia may be diffuse or plaque-like or may form blunt papillary . The biological behaviours that are exclusive to the tongue base are not clear. Four treatment response classes were defined, as follows: complete response (CR, 100% resolution); partial response (PR, 50100% resolution); no response (<50% resolution); and progression of disease (PD, tumour enlarged after treatment). Vocal cord involvement can cause choking. d. Tumour cells were positive for C-myc (200 x). CAS Departments of Pathology, Molecular Pathology Research Center, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Dongdan district Shuaifuyuan 1st, 100730, Beijing, China, Xinyu Ren,Shafei Wu,Xuan Zeng,Xiaohua Shi,Qing Ling&Zhiyong Liang, Departments of Pathology, Beijing Childrens Hospital, Capital Medical University, National Center for Childrens Health, Beijing, 100045, China, Department of Biochemistry and Molecular Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA, Department of Pathology and Otolaryngology, UC Irvine School of Medicine, UC Irvine Medical Center, Irvine, USA, You can also search for this author in Mod Pathol. Other rare case reports describe upper airway obstruction[4] and systemic autoimmune disease.[5]. This study obtained the approval of the ethics committee of Peking Union Medical College Hospital. Her IPI score was 3 (high risk group). A case of benign. Terms and Conditions, There was no cervical adenopathy, and CT of the thorax and abdomen was negative. [2], A lymph node is small, capsulated lymphoid organ that is present along the lymphatic system. St. Louis, MO: Elsevier; 2017. None of the seven patients presented systemic symptoms (body weight loss, fever and night sweating). and has since been primarily reported in the skin, breasts, gastrointestinal tract, lungs, and nasopharynx [2]. Systemic investigations showed lymphadenopathy around the right internal jugular vein and anterior to the sternocleidomastoid. Diagn Pathol 15, 30 (2020). In the orofacial region, RLH most often occurs in the oropharynx, Waldeyers tonsillar ring, the soft palate, the lateral tongue, and the floor of the mouth.2 Waldeyers ring includes the lingual and palatine tonsils, the adenoids, lymphoid follicles located on the posterolateral tongue in the area of the foliate papillae, and level 1 lymph nodes in the floor of the mouth. and transmitted securely. An official website of the United States government. Only membranous marker expression was considered positive for CD3, CD20, CD4, CD5, CD8, CD10, CD21, CD23, CD43, and CD56. Severe HBT was considered to be present when the follicles prevented the view of the epiglottis or were massively distributed through the pharynx and larynx. Others theorize that it is caused by compensatory lymphoid hyperplasia after an adenotonsillectomy.19,20 Hypertrophied lymphoid follicles in the lingual tonsils of adults has been previously associated with the signs and symptoms of GERD.10 Mamede et al9 have suggested a possible link between the hypertrophy of the base of tongue and . https://doi.org/10.1200/JCO.2005.07.155. PubMed Oral and Maxillofacial Pathology. For NHL of the head and neck, there is a logarithmic increase in incidence with increasing age [18] .The average age at disease diagnosis was 61.8years and there were no observed gender differences. Here we present a literature review and case series of seven patients with NHL of the tongue base. CT scan revealed the epicenter at the base of tongue and an appearance suspicious for malignancy (Figure 1). Positive nucleolus staining was used to identify Bcl-6, mum-1, CyclinD1, SOX11 and Ki-67. Four out of five of the DLBCL cases were NOS subtypes. The patient was kept on a three-week course of tapering prednisone and proton-pump inhibitors. Imaging and pathological findings of DLBCL (case 5). Epub 2016 Sep 17. Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Hypermethylation of CpG islands in p16 as a prognostic factor for diffuse large B-cell lymphoma in a high-risk group. Formalin-fixed, paraffin-embedded tissue blocks of enrolled cases were used to make three-micrometer-thick sections. The role of EBV in the pathogenesis of diffuse large B cell lymphoma. Article Reported cases involve the conjunctiva, liver, gastrointestinal tract, stomach, lungs, paranasal sinuses, and many cutaneous areas. Baran et al. While the etiology is poorly understood, a number of previous theories exist, which are included here in the context of a literature review. Benign lymphoid hyperplasia is a benign proliferation of lymphoid tissue in response to external irritation and occurrence within oral cavity is rare. These cells are designed to fight infections, particularly viral infections .. ENT manifestations of gastroesophageal reflux. Shimada K. Molecular pathogenesis and treatment strategy in diffuse large B-cell lymphoma. 2014;3:731. https://doi.org/10.1186/2193-1801-3-731. However, HPV infections have been identified with increasing frequency in patients with oropharyngeal squamous cell carcinoma, which is a predisposing risk factor [29]. Baran M, Canoz O, Altuntas H, Sivgin S, Cetin M, Yay A, Ketenci S. Immunohistochemical investigation of P16, P53 and Ki-67's prognostic values in diffuse large B-cell lymphomas. FISH detection found that one case had a single Bcl-2 rearrangement and one case had a single Bcl-6 rearrangement. Springerplus. Three patients are alive with disease and 2 are alive without disease. 4). This distribution is similar to that in previous reports [18,19,20,21,22] .The most common location was the base of the tongue. https://doi.org/10.1182/blood-2003-05-1545. However, this index markedly increases to 4% (4/101) among patients with pharyngolaryngeal signs of GER and reached 7.5% (4/53) among patients presenting GER symptoms such as heartburn, regurgitation, retrosternal burning feeling, and dysphagia. These results all indicate that HPV positivity does not have much impact on the overall survival of DLBCL patients. DNA was extracted from paraffin-embedded tissue using standard DNA isolation kits (QIAGEN, 56404). Studies on the survival time for patients with DLBCL in the head and neck are controversial [24, 36, 37]; here, we added that lymphoma arising from the base of the tongue has a good prognosis. It has been historically referred to as reactive lymphoid hyperplasia or pseudolymphoma [1]. Of the DLBCL patients, 4 were not otherwise specified lymphomas (NOS) and 1 was T cell/histiocyte rich large B-cell lymphoma. Head Neck. This is the first study to report on both HPV and EBV infection status in tongue base lymphoma. ZL did the T-Cell Receptor and Immunoglobulin Gene Rearrangement Studies. The https:// ensures that you are connecting to the A case of benign lymphoid hyperplasia (BLH) of the tongue is reported. However, HCV infection did not have a significant impact on the overall survival or event-free survival of DLBCL patients [31].HPV infection developing in this site might be due to low immunity from B cell lymphoma or HPV contributing to the development of lymphoma. https://doi.org/10.1111/aos.12189. 5760, 1993. World J Gastroenterol. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Careers. Lymphoid hyperplasia at the base of the tongue. Imaging and pathological findings of MCL (case 2). HPV is considered to be associated with the occurrence of oropharyngeal squamous cell carcinoma [8], therefore, we detected the infection status of the the two viruses in lymphoma of the base of the tongue. 2023 Endeavor Business Media, LLC. Etemad-Moghadam S, Tirgary F, Keshavarz S, Alaeddini M. Head and neck non-Hodgkin's lymphoma: a 20-year demographic study of 381 cases. For DNA detection of high-riskin situ HPV infection, biotin-labelled HPV probe solutions (Leica, Newcastle, UK) were added to formalin-fixed, paraffin-embedded tissue sections. Burkitt's lymphoma of the base of the tongue: a case report and review of the literature. Although nearly 10% of DLBCL cases are reported to be EBV positive and are mainly seen in elderly people [28], EBV was not detected in any of our DLBCL cases. Lymphoma cases were selected from 2010 to 2017 in PUMCH, and all cases were reviewed to identify lymphomas arising from the base of the tongue instead of other primary sites. Results came back "lymphoid hyperplasia". PubMed The condition mainly affects adult patients, ranging. or a reactive lymphoid proliferation to an unknown antigenic stimulation [2]. As shown in Table1, all primary lesion locations were considered at the base of the tongue. official website and that any information you provide is encrypted All gene rearrangement studies were performed according to the standard assay procedure, and the results were interpreted according to the assay instructions as described previously [10]. All these factors might explain why the patient survived only 3months after diagnosis although he was in an early stage and had a low IPI score. PMC The phenomenon was observed in our PTCL case and is also mentioned in Steve As research [13]. Clipboard, Search History, and several other advanced features are temporarily unavailable. 2000 Apr;122(4):607-10. doi: 10.1067/mhn.2000.98362. e. HPV DNA ISH showed brown punctate dots in the tumour cell nucleus or cytoplasm (400x).f. Radiology. 1987;149:57581. This entity was first described in 1973 by Adkins. Work-up of globus: assessing the benefits of neck ultrasound and videofluorography. he started bty saying 90% of urgent referrals were viral so should be fine. 37, no. Polyclonal lymphoid proliferation with immunohistochemistry stains for kappa or lambda light chains are diagnostic. The obstructive lesion was biopsied, and specimens were sent fresh for lymphoma histopathology protocol. 2010;39:86972. No progression to malignancy has been reported, although one multisite case within the oral cavity was found to represent MALT-type lymphoma [1]. Imaging showed a well-bordered cystic mass (2cm in diameter) at the right base of the tongue that extended into the pharynx, and so a biopsy was performed. First described in 1973 by Adkins both HPV and EBV infection status in tongue base the! 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