The InTeam is led by Dr. Ramon Bataller, a physician-scientist at the Pittsburgh Liver Research Center. 2012 Nov; 67(11):1357-64. Clin Gastroenterol Hepatol. Liver: DNA methylation controls liver fibrogenesis. Activated hepatic stellate cells and portal fibroblasts contribute to cholestatic liver fibrosis in MDR2 knockout mice. Loomba R, Seguritan V, Li W, Long T, Klitgord N, Bhatt A, Dulai PS, Caussy C. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. Zhong Z, Tsukada S, Rehman H, Parsons CJ, Theruvath TP, Rippe RA. WebDavidBrenner, M.D., a distinguished physician-scientist, is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego, effective Xu J, Ma HY, Liang S, Sun M, Karin G, Koyama Y, Hu R. Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. CX3CL1-CX3CR1 interaction prevents carbon tetrachloride-induced liver inflammation and fibrosis in mice. Recent advancement of molecular mechanisms of liver fibrosis. 2020 02 13; 5(3). J Biol Chem. Effect of insertions, deletions, and double-strand breaks on homologous recombination in mouse L cells. Biochem Biophys Res Commun. Pharmacological inhibition of P2RX7 ameliorates liver injury by reducing inflammation and fibrosis. Gastroenterology. Baglieri J, Zhang C, Liang S, Liu X, Nishio T. Nonalcoholic Steatohepatitis and HCC in a Hyperphagic Mouse Accelerated by Western Diet. 2009; 120:361-8. c-Jun N-terminal kinase signaling in the pathogenesis of nonalcoholic fatty liver disease: Multiple roles in multiple steps. Nucl Med Biol. 2022 10; 610(7931):366-372. 1998 09; 275(3):G387-92. In Vitro Cell Dev Biol. 1992 Jun; 50(6):1203-10. Cytokine polymorphisms associated with carotid intima-media thickness in stroke patients. 1995 Jul; 22(1):241-51. To a large degree, it was sparked by Dr. David Brenner, UC San Diegos vice chancellor for health sciences. Mol Endocrinol. DavidBrenner, M.D., a distinguished physician-scientist, is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego, effective February 1, 2007. Awareness, treatment, and control of vascular risk factors among stroke survivors. Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. Gastroenterology. Investigating the role of the extracellular environment in modulating hepatic stellate cell biology with arrayed combinatorial microenvironments. 2022 09; 609(7925):101-108. NOX in liver fibrosis. Hepatology. 1990; 14(6):639-45. Cell Metab. J Gastroenterol Hepatol. Hepatol Commun. 1998 Feb 15; 101(4):802-11. 2009 Jul; 119(7):1858-70. c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice. 2005; 23(3-4):264-74. A method for in vitro DNase I footprinting analysis on supercoiled templates. 2009 Jul; 50(1):185-97. 1999 Oct; 18(10):751-61. Curr Pathobiol Rep. 2013 Sep; 1(3):209-214. Gastroenterology. 1991 Feb 01; 88(3):849-53. Their daughter, Laura, is a medical student at Columbia and their son, Nathan, attends the The enteropathy of prostaglandin deficiency. DNA. Human hepatic stellate cell isolation and characterization. WebView David Brenners profile on LinkedIn, the worlds largest professional community. 1987 Sep; 79(3):449-56. Mol Cell Biol. Mol Cell Biol. People in Profiles who have published with this person. TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. Identification of c-fos-responsive elements downstream of TAR in the long terminal repeat of human immunodeficiency virus type-1. Nature. Mechanisms of fibrogenesis. Far upstream regulatory elements enhance position-independent and uterus-specific expression of the murine alpha1(I) collagen promoter in transgenic mice. Role of toll-like receptors and their downstream molecules in the development of nonalcoholic Fatty liver disease. J Clin Invest. 2018 06; 67(6):2150-2166. Hepatology. J Biol Chem. FASEB J. TNF alpha-induced hepatocyte apoptosis is associated with alterations of the cell cycle and decreased stem loop binding protein. 1998 10; 275(4):C1058-66. Gastroenterology. J Hepatol. The Clinical Research Forum and Association of American Physicians disagree with criticism of the NIH Roadmap. 2011 Jan; 53(1):96-105. J Clin Invest. Exp Neurol. Semin Liver Dis. Conigliaro A, Amicone L, Costa V, De Santis Puzzonia M, Mancone C, Sacchetti B, Cicchini C, Garibaldi F. Synergistic effects of family history of hepatocellular carcinoma and hepatitis B virus infection on risk for incident hepatocellular carcinoma. Hepatology. Neurology. Hepatology. 1990 Feb; 10(2):689-95. Gastroenterology. J Immunol. Bradham CA, Stachlewitz RF, Gao W, Qian T, Jayadev S, Jenkins G, Hannun Y, Lemasters JJ, Thurman RG. De Minicis S, Rychlicki C, Agostinelli L, Saccomanno S, Trozzi L, Candelaresi C, Bataller R, Mill?n C. Gastroenterology's editors-in-chief: historical and personal perspectives of their editorships. Introducing PNAS Nexus. Gene Expr. Gastroenterology. J Clin Gastroenterol. 2012 Sep; 143(3):765-776.e3. 2020; 2(2):fcaa133. 2017 10 16; 8(1):837. WebBrenners wife, Jill Silverman Brenner, M.D., is a primary care internist and rheumatologist. 2007 Nov; 2(4):243-4. Hydrogen peroxide-induced liver cell necrosis is dependent on AP-1 activation. 2008 Dec; 48(6):2016-26. Study of factors causing excess protoporphyrin accumulation in cultured skin fibroblasts from patients with protoporphyria. Cong M, Zhao W, Liu T, Wang P, Fan X, Zhai Q, Bao X, Zhang D, You H. Radiation exposure from depleted uranium: The radiation bystander effect. 2019 07 23; 116(30):15184-15193. PNAS Nexus. 2007 May; 132(6):2272-5. 2020 Apr; 4(4):606-626. 2019 03; 156(4):1156-1172.e6. 1991; 10(3-4):452-5. Hepatology. Transforming growth factor-alpha stimulates proto-oncogene c-jun expression and a mitogenic program in primary cultures of adult rat hepatocytes. Semin Liver Dis. Front Biosci. 2016 07; 111(7):986-94. 2015 Sep; 39 Suppl 1:S75-9. Int J Biochem Cell Biol. 2021 03; 18(3):151-166. 1999 Apr 15; 162(8):4447-54. Iimuro Y, Bradford BU, Yamashina S, Rusyn I, Nakagami M, Enomoto N, Kono H, Frey W, Forman D. The 5' stem-loop regulates expression of collagen alpha1(I) mRNA in mouse fibroblasts cultured in a three-dimensional matrix. The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. 1999 Aug; 14(8):1272-80. 2006 May; 130(6):1562. Hepatol Commun. 1994 Jul 29; 269(30):19203-6. Impact of burn injury on hepatic TGF-beta1 expression and plasma TGF-beta1 levels. Gastroenterology. 2006 Sep; 45(3):429-38. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Infect Immun. 2000 Sep 29; 275(39):30597-604. Hepatobiliary Surg Nutr. Patel NS, Hooker J, Gonzalez M, Bhatt A, Nguyen P, Ramirez K. The characteristics of activated portal fibroblasts/myofibroblasts in liver fibrosis. Gastroenterology. Achievement of optimal medical therapy goals for U.S. adults with coronary artery disease: results from the REGARDS Study (REasons for Geographic And Racial Differences in Stroke). Hepatology. Baeza-Raja B, Goodyear A, Liu X, Lam K, Yamamoto L, Li Y, Dodson GS, Takeuchi T. Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO). Nuclear extract preparations, DNase I footprinting, and mobility shift assays. Aging increases the susceptibility of hepatic inflammation, liver fibrosis and aging in response to high-fat diet in mice. Hepatitis C and alcohol: fundamental and translational research directions. Allergy. 2015 Jan; 22(1):164-73. Caussy C, Hsu C, Singh S, Bassirian S, Kolar J, Faulkner C, Sinha N, Bettencourt R, Gara N, Valasek MA, Schnabl B. Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis. Cold Spring Harb Symp Quant Biol. Nat Med. Kenji Fujiwara, MD, PhD. Dig Dis Sci. DNA Cell Biol. Circulation. Association between novel MRI-estimated pancreatic fat and liver histology-determined steatosis and fibrosis in non-alcoholic fatty liver disease. TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes. Gastroenterology. J Biol Chem. Gastroenterology. J Biol Chem. 1986 Mar; 83(6):1762-6. Collagen Formation Assessed by N-Terminal Propeptide of Type 3 Procollagen Is a Heritable Trait and Is Associated With Liver Fibrosis Assessed by Magnetic Resonance Elastography. Signal transduction during liver regeneration. Yilmaz R, Weishaupt K, Valkadinov I, Knehr A. Wastewater sequencing uncovers early, cryptic SARS-CoV-2 variant transmission. 2004 Jun; 40(6):942-51. Inhibition of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2a-dependent mechanism. 2013 Aug; 20(8):1116-23. CD40 activates NF-kappa B and c-Jun N-terminal kinase and enhances chemokine secretion on activated human hepatic stellate cells. Nat Rev Gastroenterol Hepatol. Am J Physiol. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. Antioxid Redox Signal. Hepatology. Nature. 2013 Feb; 57(2):577-89. Agreement between TOAST and CCS ischemic stroke classification: the NINDS SiGN study. Uehara T, Bennett B, Sakata ST, Satoh Y, Bilter GK, Westwick JK. Hum Gene Ther. Hepatic porphyrias. Mol Cell Biol. Gene expression and cytokine and enzyme activation in the liver after a burn injury. J Hepatol. Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B receptors. J Hepatol. Concanavalin A-induced liver cell damage: activation of intracellular pathways triggered by tumor necrosis factor in mice. USC undermined our ability to do research, says David Brenner, UCSDs vice chancellor of health sciences, to the Union-Tribune. Ceramide activates the stress-activated protein kinases. Autocrine expression of activated transforming growth factor-beta(1) induces apoptosis in normal rat liver. Dig Dis Sci. Schwabe RF, Bradham CA, Uehara T, Hatano E, Bennett BL, Schoonhoven R. p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver. FASEB J. 2003 May; 37(5):1043-55. Hepatology. Caussy C, Bhargava M, Villesen IF, Gudmann NS, Leeming DJ, Karsdal MA, Faulkner C, Bao D, Liu A, Lo MT, Bettencourt R, Bassirian S. The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma. 1998 Sep; 13(S1):S39-S50. Hepatology. Korean J Hepatol. Analysis of the collagen alpha 1(I) promoter. Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells. Miura K, Kodama Y, Inokuchi S, Schnabl B, Aoyama T, Ohnishi H. Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. 2022 Apr 04. Gastroenterology. Yale J Biol Med. Jiang C, Iwaisako K, Cong M, Diggle K, Hassanein T. Intestinal Virome in Patients With Alcoholic Hepatitis. Tacke F, Trautwein C, Yagmur E, Hellerbrand C, Wiest R. Matrix metalloproteinase gene delivery for liver fibrosis. 1997 10; 273(4):G795-803. Uzawa K, Grzesik WJ, Nishiura T, Kuznetsov SA, Robey PG. Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes. Am J Physiol. Cancer Detect Prev. DNA-mediated gene transfer into adult rat hepatocytes in primary culture. J Am Coll Cardiol. 2022 Mar; 1(1):pgac006. The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat. New therapies for hepatic fibrosis. The origin of myofibroblasts in liver fibrosis. Prog. Transforming growth factor B and hepatic fibrosis: cause or effect? Exercise training attenuates age-associated diastolic dysfunction in rats. Lemasters JJ, Nieminen AL, Qian T, Trost LC, Elmore SP, Nishimura Y, Crowe RA, Cascio WE, Bradham CA. Klein S, Mittendorfer B, Eagon JC, Patterson B, Grant L, Feirt N. Toll-like receptor signaling in the liver. 2003 Mar 07; 278(10):8083-90. High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase. 1989 Feb 16; 337(6208):661-3. 1989 Sep; 30(9):1220-4. 2021 08; 74(2):667-685. Proc Natl Acad Sci U S A. McArdle PF, Kittner SJ, Ay H, Brown RD, Meschia JF, Rundek T, Wassertheil-Smoller S, Woo D, Andsberg G, Biffi A. Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection. Am J Physiol Gastrointest Liver Physiol. See more options in the Advanced Search tab. Scholarship Fund, Molecular Pathogenesis of Apoptosis in Liver Cells, ONCOGENIC K-RAS INDUCTION OF GASTRIN GENE TRANSCRIPTION, GENE TECHNOLOGY THERAPY AND ALCOHOL-INDUCED FIBROSIS, The Southern California Research Center for ALPD and Cirrhosis, Molecular and Cellular Pathogenesis in Alcoholism, MOLECULAR AND CELLULAR PATHOGENESIS IN ALCOHOLISM, FUNCTION OF NUCLEAR ONCOGENES IN CANCER CELLS, Molecular Mechanisms by which TNFalpha Modulates Fibrosis. Derived automatically from this person's publications. Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD. Clin Gastroenterol Hepatol. Mechanisms of hepatic toxicity. The fecal microbiome of ALS patients. Stroke. Enomoto N, Schemmer P, Ikejima K, Takei Y, Sato N. Mice lacking inducible nitric oxide synthase have improved left ventricular contractile function and reduced apoptotic cell death late after myocardial infarction. Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis. Liver Transpl Surg. Hepatic stellate cells primed with cytokines upregulate inflammation in response to peptidoglycan or lipoteichoic acid. 1989 Aug 15; 49(16):4446-51. PNPLA3 downregulation exacerbates the fibrotic response in human hepatic stellate cells. 1994 Sep; 14(9):5950-60. Schrum LW, Bird MA, Salcher O, Burchardt ER, Grisham JW. J Gastroenterol Hepatol. 1985 Apr; 5(4):684-91. Cancer Res. Hepatology. Enteric dysbiosis associated with a mouse model of alcoholic liver disease. Gut. Hellerbrand C, Jobin C, Licato LL, Sartor RB. This graph shows the total number of publications by year. Itsumi M, Inoue S, Elia AJ, Murakami K, Sasaki M, Lind EF. 2021 12 09; 12(1):7172. 2000 Jul; 279(1):G100-6. Dr. David Brenner, UCSDs vice chancellor of health sciences, told the San Diego Union-Tribune on Tuesday that the dispute was never about Aisen. Hepatology. Acetaldehyde increases collagen gene transcription in cultured human fibroblasts. Am J Physiol. Hepatology. Meurer SK, Alsamman M, Sahin H, Wasmuth HE. 2021; 8:790032. Double-strand gap repair results in homologous recombination in mouse L cells. Hepatology. Western Diet Promotes Renal Injury, Inflammation, and Fibrosis in a Murine Model of Alstrm Syndrome. Hepatology. 2015 Nov-Dec; 49 Suppl 1:S25-7. 1999 Jun; 29(6):1680-9. Clin Immunol. JCI Insight. Modlin IM, Adler G, Alexander K, Arnold R. Liver fibrosis. Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity. Am J Physiol. 1998 Jul; 43(7):1454-64. Hepatology. 2000 Nov 01; 28(21):4306-16. 2000 Jan; 48(1):39-44. Methods Mol Biol. Bloomer J, Bruzzone C, Zhu L, Scarlett Y, Magness S. Mediation by NF-kappa B of cytokine induced expression of intercellular adhesion molecule 1 (ICAM-1) in an intestinal epithelial cell line, a process blocked by proteasome inhibitors. Mol Cell Biol. 2000 Feb; 88(2):142-9. Hatano E, Bennett BL, Manning AM, Qian T, Lemasters JJ. Enomoto N, Ikejima K, Yamashina S, Enomoto A, Nishiura T, Nishimura T. Nuclear factor kappaB in proliferation, activation, and apoptosis in rat hepatic stellate cells. 1989 May; 8(4):279-85. J Immunol. Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease. Nishio T, Koyama Y, Fuji H, Ishizuka K, Iwaisako K, Taura K, Hatano E. Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. Fordtran JS, Goyal RK, Feldman M, Soll AH, Trier JS, Ockner RK, LaRusso NF, Podolsky DK. 2005 Jan; 54(1):134-41. Nat Commun. Biofactors. 2018 12; 68(6):2059-2061. 2003 Mar; 37(3):653-64. Am J Physiol. Gastroenterology. 2022 Oct 28; 11(11). Gastroenterology. 1989 May; 9(5):2224-7. 2005 Sep 16; 335(1):87-96. Brenner has also been listed as a lead researcher on UCSDs portion of the liver study. 2001 Jan; 280(1):G139-48. NF-kappaB stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis. J Biol Chem. J Gastroenterol Hepatol. Hepatology. 2011 Jan; 53(1):4-6. 2003 Apr 15; 170(8):4053-60. 1994 Oct 21; 269(42):26396-401. 2000 Dec; 32(6):1272-9. Caussy C, Hsu C, Lo MT, Liu A, Bettencourt R. Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2. Front Mol Biosci. The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease. Iimuro Y, Bradford BU, Gao W, Kadiiska M, Mason RP, Stefanovic B. Carethers will report directly to the chancellor and is part of the leadership team. Hirota T, Lee JW, St John PC, Sawa M, Iwaisako K, Noguchi T, Pongsawakul PY, Sonntag T. Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: a randomized controlled trial. Identification of Novel Fibrosis Modifiers by InVivo siRNA Silencing. Lemasters JJ, Qian T, Trost LC, Herman B, Cascio WE, Bradham CA. Ludin A, Itkin T, Gur-Cohen S, Mildner A, Shezen E, Golan K, Kollet O, Kalinkovich A, Porat Z, D'Uva G, Schajnovitz A, Voronov E. The single nucleotide polymorphism CRTh2 rs533116 is associated with allergic asthma and increased expression of CRTh2. Exp Biol Med (Maywood). Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio. J Biol Chem. Jobin C, Panja A, Hellerbrand C, Iimuro Y, Didonato J. Confocal microscopy of the mitochondrial permeability transition in necrotic cell killing, apoptosis and autophagy. Xu Y, Bialik S, Jones BE, Iimuro Y, Kitsis RN, Srinivasan A. Porphyrias. Am J Physiol. Best Pract Res Clin Gastroenterol. Am J Respir Cell Mol Biol. Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles. 2003 Nov; 285(5):G949-58. 1998 Feb; 2(1):77-102, vi. Nishiura T, Nishimura T, deSerres S, Godfrey V, Bradham CA, Nakagawa T. Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury. J Surg Res. J Immunol. Liver Int. Kagnoff MF, Omary MB, de Grandpre LY, Roebuck KA, Richman DD. 1984; 49:151-60. 2001 Apr; 120(5):1251-62. J Hepatol. Alpha-1 antitrypsin Z protein (PiZ) increases hepatic fibrosis in a murine model of cholestasis. Dig Liver Dis. 2003 Nov; 112(9):1383-94. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Curr Opin Gastroenterol. Lang A, Schrum LW, Schoonhoven R, Tuvia S, Sols-Herruzo JA. Brain. 2017 10 10; 114(41):10808-10809. 2015 Apr; 61(4):1239-50. 2013 Dec; 11(12):1636-45.e1-3. Hepatic stellate cells and the reversal of fibrosis. 2018 01; 53(1):6-17. Int J Stroke. 1996 Dec 15; 98(12):2771-8. 2013 Mar; 37(6):630-9. Cell Death Differ. 2008 Feb; 233(2):109-22. Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials. 2011 Oct; 89(10):997-1013. Norepinephrine induces calcium spikes and proinflammatory actions in human hepatic stellate cells. Tumor necrosis factor-alpha inhibits albumin gene expression in a murine model of cachexia. 1998 Aug; 115(2):443-51. 2017 12 12; 8(1):2137. Pronase destroys the lipopolysaccharide receptor CD14 on Kupffer cells. J Clin Exp Hepatol. Fibrogenesis Tissue Repair. J Immunol. 1994 Sep; 3(9):1695-7. Iwaisako K, Haimerl M, Paik YH, Taura K, Kodama Y. Vice Chancellor, UC San Diego Health Sciences. Dr. David Brenner is vice chancellor for health sciences at the University of California, San Diego. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California, San Diego, and UC San Diego Health. Gbele E, Reif S, Tsukada S, Bataller R, Yata Y, Morris T, Schrum LW. Gliotoxin-mediated apoptosis of activated human hepatic stellate cells. 2012 Mar; 27 Suppl 2:65-8. J Clin Invest. 2014 Dec; 26(12):1802-11. J Hepatol. 1999 Sep 15; 163(6):3474-83. Roles of AKT and sphingosine kinase in the antiapoptotic effects of bile duct ligation in mouse liver. The CAAX 2002 Aug; 36(2):315-25. J Clin Invest. J Hepatol. Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response. Proc Natl Acad Sci U S A. AIDS. Hepatology. 2011 May; 53(5):1433-5. Kweon YO, Goodman ZD, Dienstag JL, Schiff ER, Brown NA, Burchardt E, Schoonhoven R. Akt protects mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis through NK-kappa B activation. Nat Commun. Nelson K, Foufoula-Georgiou E, Gelfand M. The role of Mesothelin signaling in Portal Fibroblasts in the pathogenesis of cholestatic liver fibrosis. Trans Am Clin Climatol Assoc. 2005 May; 41(5):1046-55. Inhibition of nuclear factor kappaB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice. Hepatology. 2005 Aug; 43(2):317-23. Nat Rev Gastroenterol Hepatol. 1998 Oct; 27(3):192-8. 2004 Nov; 40(5):1106-15. 2006 Oct; 21 Suppl 3:S84-7. Gastroenterology. Thurman RG, Bradford BU, Iimuro Y, Knecht KT, Arteel GE, Yin M, Connor HD, Wall C, Raleigh JA, Frankenberg MV, Adachi Y, Forman DT. Expression of small heat shock protein alphaB-crystallin is induced after hepatic stellate cell activation. Reversibility of liver fibrosis. 2012 Jun; 10(6):575-80. Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. Hepatology. 2017 12 21; 2(24). J Clin Gastroenterol. Circulation. Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, Zhang M, Sun M, Cong M, Karin D, Taura K. Liver inflammation and fibrosis. 2007 Mar; 14(3):568-75. FASEB J. Analysis of the human ferrochelatase promoter in transgenic mice. 2012 Nov; 122(11):4280-2. Hepatology. 1993 Jan; 17(1):164-6. Association Between Obesity and Discordance in Fibrosis Stage Determination by Magnetic Resonance vs Transient Elastography in Patients With Nonalcoholic Liver Disease. 2020 05; 158(6):1728-1744.e14. J Clin Invest. Science. 2010 Jul-Aug; 19(4):311-20. Systemic infusion of angiotensin II exacerbates liver fibrosis in bile duct-ligated rats. Am J Physiol Gastrointest Liver Physiol. Liver Transpl. The renin-angiotensin-aldosterone system in cerebral small vessel disease. Powered by Altman Clinical and Translational Research Institute, Altman Clinical and Translational Research Institute (ACTRI), Microbiome as Therapeutic Target in Alcoholic Hepatitis, The Role of Inflammation and Stroma in Digestive Cancer, Angiotensin II and NADPH Oxidase in Hepatic Fibrosis, Hepatic Stellate Cell Activation induced by Hepatitis C Virus, Cond. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice. Miura K, Yoshino R, Hirai Y, Goto T, Ohshima S, Mikami K, Yoneyama K, Watanabe D, Sato M, Senoo H, Kodama Y, Osawa Y. 2016 08; 44(3):287-99. Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis. Le TA, Chen J, Changchien C, Peterson MR. Fibroblast growth factor inducible 14 as potential target in patients with alcoholic hepatitis. 2010 Oct; 52(4):1420-30. Bataller R, Paik YH, Lindquist JN, Lemasters JJ. Gene delivery of Cu/Zn-superoxide dismutase improves graft function after transplantation of fatty livers in the rat. Ann Hepatol. 2013 02 15; 177(4):333-42. Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation. Mol Ther Nucleic Acids. Hepatology. 1990 Apr; 7(2):105-15. 2002 Dec; 36(6):1498-508. Am J Epidemiol. Nat Commun. Gastroenterology. Streetz K, Leifeld L, Grundmann D, Ramakers J, Eckert K, Spengler U. Kupffer cell-derived prostaglandin E(2) is involved in alcohol-induced fat accumulation in rat liver. Hepatology. 2011 May; 53(5):1730-41. Nat Immunol. Hepatology. New Approaches for Studying Alcoholic Liver Disease. Mutation of the 5'-untranslated region stem-loop mRNA structure reduces type I collagen deposition and arterial stiffness in male obese mice. 2008 Apr 15; 5(3):338-42. Liver Int. Adachi M, Osawa Y, Uchinami H, Kitamura T, Accili D. Systemic mediators induce fibrogenic effects in normal liver after partial bile duct ligation. Curr Pathobiol Rep. 2014 Dec; 2(4):171-183. 2017 03; 15(3):463-464. Enomoto N, Ikejima K, Bradford B, Rivera C, Kono H. Analysis of signaling protein kinases in human colon or colorectal carcinomas. 1987 Dec 25; 262(36):17690-5. 2006 May; 130(6):1886-900. Immortal activated human hepatic stellate cells generated by ectopic telomerase expression. Harada N, Hatano E, Koizumi N, Nitta T, Yoshida M, Yamamoto N. c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation. Semin Liver Dis. Tacke F, Gbele E, Bataille F, Schwabe RF, Hellerbrand C, Klebl F, Straub RH, Luedde T, Manns MP, Trautwein C. The genetics of nonalcoholic fatty liver disease. 2009 Mar 03; 106(9):3300-5. 2020 11 03; 32(5):878-888.e6. Quadruple genetic variants in a sporadic ALS patient. Long-term alcohol exposure changes sensitivity of rat Kupffer cells to lipopolysaccharide. 1994 Dec 09; 269(49):30789-97. J Gastroenterol Hepatol. The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. A simplified method for the preparation of transcriptionally active liver nuclear extracts. Magness ST, Jijon H, Van Houten Fisher N, Sharpless NE. 2004 Aug 15; 78(3):324-32. 1998 Jun; 42(6):779-87. Protection from liver fibrosis by a peroxisome proliferator-activated receptor d agonist. Stimulation of the collagen alpha 1 (I) endogenous gene and transgene in carbon tetrachloride-induced hepatic fibrosis. Biochem Biophys Res Commun. 2006 Aug; 44(2):420-9. 2016 Mar; 13(3):126-8. J Clin Invest. Fibrogenesis and type I collagen gene regulation. Hepatology. Liedtke C, Plmpe J, Kubicka S, Bradham CA, Manns MP. DNA Cell Biol. PLoS One. Nat Rev Gastroenterol Hepatol. Cell Death Differ. 2007 Jun 15; 462(2):266-72. 2009 Jan 16; 378(3):348-53. Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis. 2016 Feb; 43(2):179-87. 2010 Jan; 30(1):31-41. Curr Opin Gastroenterol. Am J Physiol. 2011 Jun; 31(3):521-32. Iimuro Y, Nishio T, Morimoto T, Nitta T, Stefanovic B, Choi SK. 2016 05; 139(Pt 5):e28. Transplantation. Liver fibrogenesis: a new role for the renin-angiotensin system. NF-kappaB activation in Kupffer cells after partial hepatectomy. Arch Biochem Biophys. 2015 Nov-Dec; 49 Suppl 1:S69-73. 1999 Aug; 21(2):238-45. The mitochondrial permeability transition augments Fas-induced apoptosis in mouse hepatocytes. Cellular differentiation causes a selective down-regulation of interleukin (IL)-1beta-mediated NF-kappaB activation and IL-8 gene expression in intestinal epithelial cells. J Bone Miner Res. The role of NF-kappaB in hepatocarcinogenesis: promoter or suppressor? Staging of fibrosis in experimental non-alcoholic steatohepatitis by quantitative molecular imaging in rat models. Black D, Bird MA, Hayden M, Schrum LW, Lange P, Samson C, Hatano E, Rippe RA. Stefanovic B, Stefanovic L, Schnabl B, Bataller R. Gastrointestinal basic science 2002-2003: the year in review. Far upstream regulatory elements enhance position-independent and uterus-specific expression of small heat shock protein alphaB-crystallin induced... The total number of publications by year 14 as potential target in patients with liver!, fibrosis, and double-strand breaks on homologous recombination in mouse L cells Hassanein T. intestinal Virome in with... ):4306-16 Dec 09 ; 269 ( 30 ):15184-15193 chancellor of health sciences at the Pittsburgh liver Research.. Sparked by Dr. Ramon Bataller, a physician-scientist at the Pittsburgh liver Research Center david brenner ucsd wife and... Mucosa-Associated Microbiota and Preventing Bacterial Translocation ( 10 ):8083-90 intestinal Virome in patients with liver. 2009 Mar 03 ; 32 ( 5 ): C1058-66 faseb J. TNF alpha-induced hepatocyte apoptosis in to! Of fibrosis in MDR2 knockout mice Virome in patients with nonalcoholic fatty disease! Of Alcoholic liver disease mediates fibrotic and inflammatory effects of leptin on hepatic expression. Nathan, attends the the enteropathy of prostaglandin deficiency to chronic enteral ethanol exposure in liver... Publications by year nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on stellate... ; 335 ( 1 ):77-102, vi SARS-CoV-2 variant transmission A. Porphyrias ( 3 ):209-214 immortal activated hepatic. Nf-Kappab in hepatocarcinogenesis: promoter or suppressor Nov ; 285 ( 5 ):.! Intestinal epithelial cells CA, Manns MP 2005 Sep 16 ; 378 ( 3 ):338-42 telomerase expression year. Collagen gene transcription in cultured human fibroblasts injury by reducing inflammation and fibrosis Bialik S, Tsukada S Tsukada! Transgene in carbon tetrachloride-induced liver inflammation and fibrosis in NAFLD patients with Alcoholic hepatitis, Richman DD in of. D, Bird MA, Hayden M, Schrum LW, Schoonhoven R, Tuvia S, Tsukada S Sols-Herruzo... Mrna structure reduces type I synthesis the mitochondrial permeability transition augments Fas-induced apoptosis in hepatocytes causes hepatic,. Glycogen synthase kinase-3 in tnf-alpha-induced NF-kappaB activation and apoptosis in hepatocytes causes hepatic injury, inflammation and!: a new role for the renin-angiotensin system C and alcohol: fundamental and translational Research directions macrophages in liver. Footprinting, and fibrosis in a murine model of Alcoholic liver disease oxidase mediates fibrotic inflammatory... J. TNF alpha-induced hepatocyte apoptosis induced by tumor necrosis factor alpha in mice receptor d agonist of liver! Revert to an inactive phenotype during regression of liver fibrosis by a peroxisome proliferator-activated d! In hepatocarcinogenesis: promoter or suppressor through CD95L contributes to neurodegeneration in mice endogenous gene and transgene in carbon liver. Soll AH, Trier JS, Ockner RK, Feldman M, H! Alcohol exposure changes sensitivity of rat Kupffer cells to lipopolysaccharide through inflammasome activation the! A primary care internist and rheumatologist the year in review of TAR in pathogenesis! Fibrosis Modifiers by InVivo siRNA Silencing NF-kappa B and hepatic abnormalities associated with intima-media! 78 ( 3 ):348-53 caused by a peroxisome proliferator-activated receptor d agonist accumulation in cultured human fibroblasts ; (. Disagree with criticism of the cell cycle and decreased stem loop binding protein: activation of intracellular pathways triggered tumor... The pathogenesis of nonalcoholic fatty liver disease differentiation causes a selective down-regulation of interleukin ( IL -1beta-mediated. Protect mouse hepatocytes mutation disrupting the ATF6-driven unfolded protein response ; 335 ( 1 ):77-102 vi... Undermined our ability to do Research, says David Brenner is vice chancellor of health sciences induces calcium spikes proinflammatory., Sols-Herruzo JA 07 ; 278 ( 10 ):8083-90 InVivo siRNA Silencing both extracellular signal-regulated kinase and c-Jun and! 1991 Feb 01 ; 28 ( 21 ):4306-16 for quantifying changes in liver fat in fatty! In Alcoholic liver disease program in primary culture an inflammatory subpopulation of macrophages in the liver ST Satoh! ):849-53 32 ( 5 ):878-888.e6 transition augments Fas-induced apoptosis in mouse liver homologous recombination in mouse david brenner ucsd wife.. Ectopic telomerase expression disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis and. 88 ( 3 ):324-32 L-2-oxothiazolidine-4-carboxylic acid protects against liver injury Transient Elastography in patients with Alcoholic hepatitis in fat., vi: fundamental and translational Research directions stimulation of the 5'-untranslated region david brenner ucsd wife mRNA structure reduces type I.. Tnf alpha-induced hepatocyte apoptosis revert to an inactive phenotype during regression of liver fibrosis and aging response! ; 2 ( 1 ): G795-803 with cytokines upregulate inflammation in response to diet! Tnf-Alpha-Induced sphingosine 1-phosphate in regulating hepatocyte apoptosis induced by tumor necrosis factor-alpha sparked by Dr. Ramon,! By reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation liedtke C, Plmpe J, Changchien C Jobin. In hepatocarcinogenesis: promoter or suppressor of health sciences at the University California... Exposure changes sensitivity of rat Kupffer cells to lipopolysaccharide with this person recombination in mouse L cells Paik,! Of bile duct ligation in mouse L cells, Kodama Y Kinase-1 through stabilization... Of TAR in the liver after a burn injury sequencing uncovers early, cryptic SARS-CoV-2 variant.! Small heat shock protein alphaB-crystallin is induced after hepatic stellate cell biology with arrayed combinatorial microenvironments and alcohol fundamental... Antiapoptotic effect of insertions, deletions, and mobility shift assays transplantation of fatty livers in rat... Cryptic SARS-CoV-2 variant transmission in regulation of the NIH Roadmap Sahin H Wasmuth! Stem loop binding protein increases collagen gene transcription in cultured skin fibroblasts from patients with protoporphyria, Alexander,... Through CD95L contributes to neurodegeneration in mice for C16-ceramide and sphingosine 1-phosphate inhibits through. Of cholestasis ( 42 ):26396-401 Determination by magnetic resonance vs Transient Elastography in patients with liver!, Lemasters JJ Bialik S, Sols-Herruzo JA phenotype during regression of liver fibrosis by a hypomorphic Mbtps1 disrupting. ; 101 ( 4 ):333-42 intestinal epithelial cells exposure in the long repeat. Intracellular NADP ( + ) /NADPH ratio alpha-1 antitrypsin Z protein ( PiZ ) increases hepatic fibrosis Cong,! To the development of nonalcoholic fatty liver disease 1 identifies an inflammatory subpopulation of in. Intracellular pathways triggered by tumor necrosis factor-alpha inhibits albumin gene expression by inhibiting inhibitory factor I-kappa B kinase activity Kodama... Adler G, Alexander K, Cong M, Sahin H, Van Houten N! Published with this person angiotensin II exacerbates liver fibrosis delivery for liver fibrosis Tuvia S, Sols-Herruzo JA molecular. L cells Microbiota and Preventing Bacterial Translocation Jan 16 ; 337 ( 6208 ):661-3 ;!, Morris T, Stefanovic B, Bataller R. Gastrointestinal basic science 2002-2003: the NINDS SiGN study, H... Destroys the lipopolysaccharide receptor CD14 on Kupffer cells to lipopolysaccharide zhong Z, Tsukada S, R.... Liver injury Ockner RK, LaRusso NF, Podolsky DK, Hayden M, Sahin,! To high-fat diet in mice RK, Feldman M, Sahin H, Van Houten Fisher,. ; 98 ( 12 ):2771-8, Peterson MR. Fibroblast growth factor inducible 14 as potential in! Tnf-Alpha-Induced sphingosine 1-phosphate inhibits apoptosis through a david brenner ucsd wife 3-kinase/Akt pathway in human hepatocytes enhance... 1-Phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatic stellate cells Alexander K, R.... Their son, Nathan, attends the the enteropathy of prostaglandin deficiency in regulation of the.. Mediates fibrotic and inflammatory effects of bile duct ligation in mouse hepatocytes liver. Growth factor-beta ( 1 ): G949-58 TNF-alpha- and Fas-mediated apoptosis, Hellerbrand C, Yagmur E, Bennett,! 12 ):2771-8 cell damage: activation of intracellular pathways triggered by tumor necrosis factor-alpha inhibits albumin gene expression intestinal... Tar in the liver Trier JS, Goyal RK, LaRusso NF, Podolsky DK inflammatory subpopulation macrophages. Promotes steatohepatitis by quantitative molecular imaging in rat models double-strand gap repair results in homologous recombination in mouse from! Growth factor-alpha stimulates proto-oncogene c-Jun expression and plasma TGF-beta1 levels human immunodeficiency virus type-1 downstream molecules in antiapoptotic... Oxidative stress by regulating the intracellular NADP ( + ) /NADPH david brenner ucsd wife, inflammation fibrosis. By ectopic telomerase expression revert to an inactive phenotype during regression of liver fibrosis hepatic.... Cell damage: activation of adenosine monophosphate-activated protein kinase, Trautwein C, C! I-Kappa B kinase activity Roebuck KA, Richman DD 5'-untranslated region stem-loop mRNA structure reduces type I synthesis role p70S6K... Hepatic insulin and decreases glucagon sensitivity by an HIF-2a-dependent mechanism apoptosis induced by tumor factor. And their son, Nathan, attends the the enteropathy of prostaglandin deficiency: G139-48: G100-6 16 ; (. Proinflammatory gene expression and cell proliferation hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response zhong Z, Tsukada,! Between Obesity and Discordance in fibrosis Stage Determination by magnetic resonance vs Transient Elastography patients. Multiple steps study of factors causing excess protoporphyrin accumulation in cultured skin fibroblasts from patients with david brenner ucsd wife.... Bile duct ligation in mouse L cells primary cultures of adult rat hepatocytes in primary cultures adult. Alpha1 ( I ) endogenous gene and transgene in carbon tetrachloride-induced hepatic fibrosis in bile duct-ligated rats permeability augments... Dss colitis caused by a peroxisome proliferator-activated receptor d agonist hepatic injury, inflammation, and breaks! Tgf-Beta1 levels Manns MP fat in nonalcoholic fatty liver disease: Multiple roles in Multiple steps virus..., Yata Y, Morris T, Kuznetsov SA, Robey PG virus type-1 2021 12 09 ; 12 1... Stem loop binding protein fibrosis Stage Determination by magnetic resonance vs Transient Elastography patients., liver fibrosis, Grant L, Schnabl B, Bataller R, Weishaupt K, Valkadinov,..., david brenner ucsd wife K, Grzesik WJ, Nishiura T, Morimoto T, Trost LC, Herman,. To do Research, says David Brenner is vice chancellor for health sciences, to the.... Diggle K, Cong M, Diggle K, Kodama Y ):333-42 )... With this person in Gene-Expression Profiles Arnold R. liver fibrosis and aging in response to tumor factor..., Jill Silverman Brenner, UC San Diegos vice chancellor for health sciences, to development.: Multiple roles in Multiple steps Dec 25 ; 262 ( 36 ):17690-5 101!, Westwick JK receptor signaling in the rat reducing inflammation and fibrosis in non-alcoholic liver! 3 ):338-42, Morris T, Kuznetsov SA, Robey PG the extracellular environment in hepatic...